The digital well being report (EHR) is a contributor to critical affected person hurt occurring inside a sociotechnical system. Chemotherapy ordering is a high-risk process due to the complicated nature of ordering workflows and potential detrimental results if mistaken chemotherapeutic doses are administered. Many chemotherapy ordering errors can’t be mitigated by systems-based modifications due to the restricted extent to which particular person establishments are ready to customise proprietary EHR software program. We hypothesized that simulation-based coaching may enhance suppliers’ means to establish and mitigate frequent chemotherapy ordering errors.
Pediatric hematology/oncology suppliers voluntarily participated in simulations utilizing an EHR testing (“Playground”) surroundings. The variety of security dangers recognized and mitigated by every supplier at baseline was recorded. Risks had been reviewed one-on-one after preliminary simulations and at a gaggle “lunch-and-learn” session. At three-month follow-up, repeat simulations assessed for enhancements in error identification and mitigation, and suppliers had been surveyed about prevention of real-life security occasions.
The Eight collaborating suppliers recognized and mitigated a mean of 5.5 out of 10 security dangers through the preliminary simulation, in contrast 7.four security dangers on the observe up simulation (p=0.030). Two of the suppliers (25%) reported stopping a minimum of one real-world affected person security occasion within the scientific setting on account of the preliminary coaching session. Simulation-based coaching might reduce suppliers’ susceptibility to chemotherapy ordering security vulnerabilities inside the EHR. This method could also be used when systems-based EHR enhancements are usually not possible due to restricted means to customise native cases of proprietary EHR software program.
Evaluation of Inflammatory Biomarkers in Pediatric Hematology–Oncology Patients With Bloodstream Infection
Bloodstream an infection (BSI) is a critical complication in pediatric hematology–oncology sufferers. To consider the scientific significance of C-reactive protein (CRP), procalcitonin (PCT), albumin, fibrinogen, and D-dimer as potential biomarkers to differentiate amongst varied subtypes of BSIs in pediatric sufferers with hematological and oncological illnesses, we retrieved and analyzed the medical information of pediatric hematology–oncology sufferers identified with BSI at our hospital between January 2016 and December 2017.
The demographic (intercourse and age) and scientific (major illnesses) traits, and laboratory check outcomes (white blood cell and absolute neutrophil counts, and serum CRP, PCT, albumin, fibrinogen, and D-dimer ranges) had been in contrast between nosocomial and non-nosocomial; neutropenic and non-neutropenic; and gram-positive and gram-negative BSI episodes. Of the 5 potential biomarkers evaluated (CRP, PCT, albumin, fibrinogen, and D-dimer), PCT ranges had been considerably decrease in neutropenic episodes and gram-positive BSIs (P=0.008 and P=0.001, respectively).
A complete of 125 BSI episodes had been included, together with 69 (55.2%) nosocomial circumstances, 94 (75.2%) neutropenic circumstances, and 49 (39.2%) gram-positive episodes. At a cutoff worth of 0.67 ng/mL, the diagnostic sensitivity, specificity, and optimistic/damaging predictive values of PCT for the differentiation of gram-positive and gram-negative bacterial sepsis had been 74.2%, 64.6%, 70.8%, and 65.2%, respectively. We concluded that PCT may probably function a biomarker to differentiate between gram-positive and gram-negative BSIs in pediatric hematology–oncology sufferers.
Development of a instrument to allocate inpatient specialised pharmacy assets at a complete most cancers middle
Develop an goal instrument to align the wants of inpatient providers at a Comprehensive Cancer Center with the accessible assets of hematology/oncology scientific specialist pharmacists. The shift of the pharmacy career from product-centered to patient-centered care has expanded the scope of observe of the scientific pharmacist and their means to focus on a therapeutic space. However, these specialised assets are restricted. The pharmacy division at The James Comprehensive Cancer Center at The Ohio State University Wexner Medical Center developed a instrument to objectively decide which inpatient providers would obtainessentially the mostprofit from having a hematology/oncologyscientific specialist pharmacist on their healthcare group.
A Steering Committee was created to decide the required metrics wanted throughout the 29 inpatient providers at The James, and knowledge was collected from the digital medical report. The metrics evaluated had been: affected person acuity, inpatient intravenous anticancer administrations, inpatient oral anticancer administrations, presence of an outpatient anticancer therapy plan for sufferers admitted for an inpatient keep, and the usage of high-risk hematology/oncology therapies.
 Human P16 Antibody |
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| BF0580 | Affbiotech | 200ul | EUR 376 |
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Description: Human P16 antibody detects endogenous levels of total Human P16. |
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 human Splunc2 Antibody |
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| BF0019 | Affbiotech | 200ul | EUR 376 |
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Description: human Splunc2 antibody detects endogenous levels of total human Splunc2. |
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 human VEGF Antibody |
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| E13-a001 | EnoGene | 100μg | EUR 382 |
 Human IgE antibody |
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| E22NH04-1 | EnoGene | 100ug | EUR 343 |
Human P16 Antibody |
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| abx011302-100ul | Abbexa | 100 ul | EUR 411 |
|
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 Human HER2 Antibody |
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| abx023907-100ug | Abbexa | 100 ug | EUR 453 |
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 Human Merlin Antibody |
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| abx023908-100ug | Abbexa | 100 ug | EUR 453 |
|
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 Human CRP Antibody |
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| abx023919-10ml | Abbexa | 10 ml | EUR 356 |
|
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 Human IgM Antibody |
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| abx015702-100ul | Abbexa | 100 ul | EUR 411 |
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human Splunc2 Antibody |
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| abx015999-100ug | Abbexa | 100 ug | EUR 411 |
|
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 Human IgA Antibody |
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| abx019197-1mg | Abbexa | 1 mg | EUR 565 |
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 Human IgG Antibody |
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| abx019200-5mg | Abbexa | 5 mg | EUR 230 |
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Human IgA Antibody |
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| abx234075-100ug | Abbexa | 100 ug | EUR 551 |
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Human IgA Antibody |
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| abx234076-100ug | Abbexa | 100 ug | EUR 551 |
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Human IgG Antibody |
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| abx234077-100ug | Abbexa | 100 ug | EUR 551 |
|
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 Human Albumin antibody |
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| 70R-7567 | Fitzgerald | 1 mg | EUR 140 |
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Description: Affinity purified Goat polyclonal Human Albumin antibody |
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 Human PPP2R1A Antibody |
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| 35179-05111 | AssayPro | 150 ug | EUR 261 |
 Human Cystathionase Antibody |
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| 35613-05111 | AssayPro | 150 ug | EUR 261 |
 Human Amisyn Antibody |
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| 35627-05111 | AssayPro | 150 ug | EUR 261 |
 Human PDCL3 Antibody |
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| 35628-05111 | AssayPro | 150 ug | EUR 261 |
 Human LRP2BP Antibody |
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| 35629-05111 | AssayPro | 150 ug | EUR 261 |
 Human Enterokinase Antibody |
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| 35631-05111 | AssayPro | 150 ug | EUR 261 |
 Human GAD67 Antibody |
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| 35633-05111 | AssayPro | 150 ug | EUR 261 |
 Human CYB5R3 Antibody |
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| 35634-05111 | AssayPro | 150 ug | EUR 261 |
 Human CD37 Antibody |
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| 35636-05111 | AssayPro | 150 ug | EUR 261 |
 Human SH3GL3 Antibody |
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| 35637-05111 | AssayPro | 150 ug | EUR 261 |
 Human XRCC2 Antibody |
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| 35678-05111 | AssayPro | 150 ug | EUR 261 |
 Human EEF1A1 Antibody |
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| 35679-05111 | AssayPro | 150 ug | EUR 261 |
 Human GFPT1 Antibody |
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| 35680-05111 | AssayPro | 150 ug | EUR 261 |
 Human SDF2 Antibody |
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| 35683-05111 | AssayPro | 150 ug | EUR 261 |
 Human LCMT1 Antibody |
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| 35684-05111 | AssayPro | 150 ug | EUR 261 |
 Human HMBS Antibody |
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| 35685-05111 | AssayPro | 150 ug | EUR 261 |
 Human CD1E Antibody |
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| 35696-05111 | AssayPro | 150 ug | EUR 261 |
 Human CD3G Antibody |
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| 35697-05111 | AssayPro | 150 ug | EUR 261 |
 Human CD9 Antibody |
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| 35698-05111 | AssayPro | 150 ug | EUR 261 |
 Human UBE2L3 Antibody |
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| 35778-05111 | AssayPro | 150 ug | EUR 261 |
 Human PITPN Antibody |
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| 34035-05111 | AssayPro | 150 ug | EUR 261 |
 Human GTSF1 Antibody |
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| 35138-05111 | AssayPro | 150 ug | EUR 261 |
 Human Hemopexin Antibody |
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| 35139-05111 | AssayPro | 150 ug | EUR 261 |
 Human LOX Antibody |
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| 35140-05111 | AssayPro | 150 ug | EUR 261 |
 Human Thrombin Antibody |
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| 35147-05111 | AssayPro | 150 ug | EUR 261 |
 Human UBTD2 Antibody |
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| 33376-05111 | AssayPro | 150 ug | EUR 261 |
 Human LOC51255 Antibody |
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| 33377-05111 | AssayPro | 150 ug | EUR 261 |
 Human IFT20 Antibody |
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| 33379-05111 | AssayPro | 150 ug | EUR 261 |
 Human COMMD9 Antibody |
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| 33380-05111 | AssayPro | 150 ug | EUR 261 |
 Human UBE2M Antibody |
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| 33381-05111 | AssayPro | 150 ug | EUR 261 |
 Human CIAO1 Antibody |
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| 33382-05111 | AssayPro | 150 ug | EUR 261 |
 Human SMUG1 Antibody |
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| 33383-05111 | AssayPro | 150 ug | EUR 261 |
 Human NMRAL1 Antibody |
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| 33384-05111 | AssayPro | 150 ug | EUR 261 |
 Human SSR4 Antibody |
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| 33385-05111 | AssayPro | 150 ug | EUR 261 |
 Human LIN7C Antibody |
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| 33386-05111 | AssayPro | 150 ug | EUR 261 |
 Human ICT1 Antibody |
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| 33387-05111 | AssayPro | 150 ug | EUR 261 |
 Human IRGM Antibody |
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| 33388-05111 | AssayPro | 150 ug | EUR 261 |
 Human SH3BGRL3 Antibody |
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| 33389-05111 | AssayPro | 150 ug | EUR 261 |
 Human PAFAH1B3 Antibody |
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| 33393-05111 | AssayPro | 150 ug | EUR 261 |
 Human MST Antibody |
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| 33394-05111 | AssayPro | 150 ug | EUR 261 |
 Human SULT1B1 Antibody |
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| 33395-05111 | AssayPro | 150 ug | EUR 276 |
 Human TBC1D13 Antibody |
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| 33396-05111 | AssayPro | 150 ug | EUR 261 |
 Human PGPEP1 Antibody |
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| 33397-05111 | AssayPro | 150 ug | EUR 261 |
 Human PQBP1 Antibody |
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| 33398-05111 | AssayPro | 150 ug | EUR 261 |
 Human MEMO1 Antibody |
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| 33400-05111 | AssayPro | 150 ug | EUR 261 |
 Human EMG1 Antibody |
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| 33401-05111 | AssayPro | 150 ug | EUR 261 |
 Human BCMA Antibody |
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| 33402-05111 | AssayPro | 150 ug | EUR 261 |
 Human ULBP4 Antibody |
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| 33403-05111 | AssayPro | 150 ug | EUR 261 |
 Human CDK2AP2 Antibody |
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| 33405-05111 | AssayPro | 150 ug | EUR 261 |
 Human UXT Antibody |
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| 33407-05111 | AssayPro | 150 ug | EUR 261 |
 Human ESM1 Antibody |
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| 33408-05111 | AssayPro | 150 ug | EUR 261 |
 Human DBNDD1 Antibody |
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| 33409-05111 | AssayPro | 150 ug | EUR 261 |
 Human DSTN Antibody |
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| 33410-05111 | AssayPro | 150 ug | EUR 261 |
 Human CAB39L Antibody |
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| 33411-05111 | AssayPro | 150 ug | EUR 261 |
 Human FBP2 Antibody |
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| 33412-05111 | AssayPro | 150 ug | EUR 261 |
 Human POLR2E Antibody |
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| 33414-05111 | AssayPro | 150 ug | EUR 261 |
 Human FDCSP Antibody |
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| 33416-05111 | AssayPro | 150 ug | EUR 261 |
 Human CD33 Antibody |
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| 33418-05111 | AssayPro | 150 ug | EUR 261 |
 Human PSMD9 Antibody |
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| 33419-05111 | AssayPro | 150 ug | EUR 261 |
 Human Neurotensin Antibody |
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| 33420-05111 | AssayPro | 150 ug | EUR 261 |
 Human HBXIP Antibody |
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| 33422-05111 | AssayPro | 150 ug | EUR 261 |
 Human GCLM Antibody |
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| 33427-05111 | AssayPro | 150 ug | EUR 261 |
 Human UBE2J2 Antibody |
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| 33428-05111 | AssayPro | 150 ug | EUR 261 |
 Human IMP3 Antibody |
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| 33429-05111 | AssayPro | 150 ug | EUR 261 |
 Human CLEC2B Antibody |
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| 33430-05111 | AssayPro | 150 ug | EUR 261 |
 Human CNRIP1 Antibody |
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| 33431-05111 | AssayPro | 150 ug | EUR 261 |
 Human FGF2 Antibody |
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| 33432-05111 | AssayPro | 150 ug | EUR 261 |
 Human AP3S1 Antibody |
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| 33434-05111 | AssayPro | 150 ug | EUR 261 |
 Human KCDT15 Antibody |
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| 33437-05111 | AssayPro | 150 ug | EUR 261 |
 Human SAMD13 Antibody |
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| 33438-05111 | AssayPro | 150 ug | EUR 261 |
 Human USP14 Antibody |
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| 33439-05111 | AssayPro | 150 ug | EUR 261 |
 Human SEC22L1 Antibody |
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| 33441-05111 | AssayPro | 150 ug | EUR 261 |
 Human HOPX Antibody |
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| 33444-05111 | AssayPro | 150 ug | EUR 261 |
 Human LDOC1L Antibody |
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| 33445-05111 | AssayPro | 150 ug | EUR 261 |
 Human BPI Antibody |
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| 33446-05111 | AssayPro | 150 ug | EUR 261 |
 Human ASGR2 Antibody |
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| 33449-05111 | AssayPro | 150 ug | EUR 261 |
 Human CLNS1A Antibody |
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| 33450-05111 | AssayPro | 150 ug | EUR 261 |
 Human ACAT1 Antibody |
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| 33451-05111 | AssayPro | 150 ug | EUR 261 |
 Human MFAP4 Antibody |
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| 33454-05111 | AssayPro | 150 ug | EUR 261 |
 Human UBE2C Antibody |
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| 33456-05111 | AssayPro | 150 ug | EUR 261 |
 Human NDRG2 Antibody |
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| 33458-05111 | AssayPro | 150 ug | EUR 261 |
 Human TDG Antibody |
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| 33459-05111 | AssayPro | 150 ug | EUR 261 |
 Human TULP1 Antibody |
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| 33460-05111 | AssayPro | 150 ug | EUR 261 |
 Human ARH3 Antibody |
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| 33462-05111 | AssayPro | 150 ug | EUR 261 |
 Human MitoNEET Antibody |
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| 33463-05111 | AssayPro | 150 ug | EUR 261 |
 Human RNF4 Antibody |
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| 33464-05111 | AssayPro | 150 ug | EUR 261 |
 Human RPC8 Antibody |
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| 33465-05111 | AssayPro | 150 ug | EUR 261 |
 Human ULBP1 Antibody |
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| 33466-05111 | AssayPro | 150 ug | EUR 261 |
 Human TRC40 Antibody |
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| 33467-05111 | AssayPro | 150 ug | EUR 261 |
 Human KIN Antibody |
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| 33468-05111 | AssayPro | 150 ug | EUR 261 |
 Human UMPS Antibody |
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| 33470-05111 | AssayPro | 150 ug | EUR 261 |
 Human C11orf79 Antibody |
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| 33471-05111 | AssayPro | 150 ug | EUR 261 |
 Human Lyn Antibody |
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| 33472-05111 | AssayPro | 150 ug | EUR 261 |
 Human Plunc Antibody |
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| 33473-05111 | AssayPro | 150 ug | EUR 261 |
 Human RAP2B Antibody |
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| 33475-05111 | AssayPro | 150 ug | EUR 261 |
 Human DcR1 Antibody |
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| 33476-05111 | AssayPro | 150 ug | EUR 261 |
 Human FGF8 Antibody |
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| 33478-05111 | AssayPro | 150 ug | EUR 261 |
 Human FGF20 Antibody |
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| 33479-05111 | AssayPro | 150 ug | EUR 261 |
 Human MyD88 Antibody |
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| 33480-05111 | AssayPro | 150 ug | EUR 261 |
 Human RPC39 Antibody |
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| 33481-05111 | AssayPro | 150 ug | EUR 261 |
 Human SAR1B Antibody |
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| 33482-05111 | AssayPro | 150 ug | EUR 261 |
 Human TROP2 Antibody |
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| 33483-05111 | AssayPro | 150 ug | EUR 261 |
 Human COQ9 Antibody |
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| 33484-05111 | AssayPro | 150 ug | EUR 261 |
 Human IP10 Antibody |
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| 33490-05111 | AssayPro | 150 ug | EUR 261 |
 Human CD201 Antibody |
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| 33527-05111 | AssayPro | 150 ug | EUR 261 |
Human IgM Antibody |
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| 49395-100ul | SAB | 100ul | EUR 333 |
Human IgM Antibody |
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| 49395-50ul | SAB | 50ul | EUR 239 |
human Splunc2 Antibody |
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| 48450-100ul | SAB | 100ul | EUR 333 |
human Splunc2 Antibody |
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| 48450-50ul | SAB | 50ul | EUR 239 |
 Human Visfatin Antibody |
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| 48609-05011 | AssayPro | 150 ug | EUR 217 |
 Human Vitronectin Antibody |
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| 48629-05011 | AssayPro | 150 ug | EUR 217 |
 Human IgG4 Antibody |
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| 48305-100ul | SAB | 100ul | EUR 333 |
Human IgG4 Antibody |
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| 48305-50ul | SAB | 50ul | EUR 239 |
 Human Galanin Antibody |
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| 10871-05011 | AssayPro | 150 ug | EUR 217 |
 Human Gastrin Antibody |
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| 10901-05011 | AssayPro | 150 ug | EUR 217 |
 Human Ghrelin Antibody |
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| 10931-05011 | AssayPro | 150 ug | EUR 217 |
 Human TFPI Antibody |
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| 10-2815 | Fitzgerald | 500 ug | EUR 727 |
|
Description: Mouse anti-Human TFPI Antibody |
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 Human IgM antibody |
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| 10-3149 | Fitzgerald | 1 mg | EUR 219 |
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Description: Mouse Monoclonal Human IgM antibody |
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 Human IgG antibody |
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| 10-3150 | Fitzgerald | 1 mg | EUR 208 |
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Description: Mouse Monoclonal Human IgG antibody |
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 Human IgA antibody |
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| 10-3151 | Fitzgerald | 1 mg | EUR 219 |
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Description: Mouse Monoclonal Human IgA antibody |
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 Human IgE antibody |
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| 10-3152 | Fitzgerald | 1 mg | EUR 219 |
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Description: Mouse Monoclonal Human IgE antibody |
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 Human Nuclei antibody |
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| 10R-8371 | Fitzgerald | 100 ul | EUR 457 |
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Description: Mouse monoclonal Human Nuclei antibody |
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Human IgG antibody |
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| 10R-8446 | Fitzgerald | 100 ul | EUR 393 |
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Description: Mouse monoclonal Human IgG antibody |
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Human IgM antibody |
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| 10R-8447 | Fitzgerald | 100 ul | EUR 393 |
|
Description: Mouse monoclonal Human IgM antibody |
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Human IgA antibody |
|||
| 10R-8448 | Fitzgerald | 100 ul | EUR 393 |
|
Description: Mouse monoclonal Human IgA antibody |
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 Human Albumin Antibody |
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| 12001-05011 | AssayPro | 150 ug | EUR 217 |
 Human Apotransferrin Antibody |
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| 12091-05011 | AssayPro | 150 ug | EUR 217 |
 Human Azurocidin Antibody |
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| 12100-05011 | AssayPro | 150 ug | EUR 217 |
 Human Chylomicrons Antibody |
|||
| 12111-05011 | AssayPro | 150 ug | EUR 217 |
Human Hemopexin Antibody |
|||
| 12131-05011 | AssayPro | 150 ug | EUR 217 |
 Human Recoverin Antibody |
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| 12151-05011 | AssayPro | 150 ug | EUR 217 |
 Human Angiotensinogen Antibody |
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| 11013-05011 | AssayPro | 150 ug | EUR 217 |
 Human Guanylin Antibody |
|||
| 11021-05011 | AssayPro | 150 ug | EUR 217 |
 Human Pepsinogen Antibody |
|||
| 11224-05011 | AssayPro | 150 ug | EUR 217 |
 Human Catalase Antibody |
|||
| 11241-05011 | AssayPro | 150 ug | EUR 217 |
 Human Haptoglobin Antibody |
|||
| 11371-05011 | AssayPro | 150 ug | EUR 217 |
 Human Leptin Antibody |
|||
| 11411-05011 | AssayPro | 150 ug | EUR 217 |
 Human Plasmin Antibody |
|||
| 11481-05011 | AssayPro | 150 ug | EUR 217 |
Human Thrombin Antibody |
|||
| 11571-05011 | AssayPro | 150 ug | EUR 217 |
 Human GPIIbIIIa Antibody |
|||
| 11587-05011 | AssayPro | 150 ug | EUR 217 |
Natural killer (NK) perform defects have been seen in lots of hematological malignancies, together with acute myeloid leukemia (AML). AML is related to poor human leukocyte antigen (HLA) expression on leukemia blasts which grow to be targets for killing by NK and pure killer-like T (NKT) cells. However, NK and NKT cells are usually not efficient in killing autologous leukemia blasts, possibly due to quantity or practical abnormalities. The intention of the work was to detect the quantity and proportion of NK and NKT cells in sufferers with AML and the affect of their proportion on the prognosis, response to therapy and survival.
Bone marrow and peripheral blood samples had been collected from 50 grownup sufferers identified as de novo AML who introduced to the Hematology Unit within the Oncology Center Mansoura University (OCMU) at time of analysis. NK and NKT cells had been detected by utilizing immunophenotyping by expression of cell floor and cytoplasmic markers (anti-CD3 fluorescein isothiocyanate (FITC), anti-CD16/56 phycoerythrin (PE)).